Cardiology and Angiology: An International Journal <p style="text-align: justify;"><strong>Cardiology and Angiology: An International Journal (ISSN:&nbsp;2347-520X)</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/CA/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of ‘Cardiology and Angiology research’. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> en-US (Cardiology and Angiology: An International Journal) (Cardiology and Angiology: An International Journal) Thu, 12 Mar 2020 08:46:13 +0000 OJS 60 Predictive Role of Cardiac Troponin I, Creatine Kinase-Mb and Electrocardiogram in Early Assessment of Acute Cardiotoxicity in Patients Poisoned by Cardiotoxic Drugs and Toxins <p><strong>Background: </strong>In spite speedy development of clinical toxicology researches and protocols cardiovascular failure in severe acute intoxication remains a leading cause of death. Early cardiovascular risk assessment in acutely intoxicated patients is a must nowadays.</p> <p>This study aims to evaluate the role of ECG, serum cardiac troponin I (cTnI) and creatine kinase myocardial band (CK-MB) for early detection of cardio-toxicity in acutely poisoned patients.</p> <p><strong>Methods:</strong> Prospective study was carried on100 patients with acute cardiotoxicity by drugs and toxins known to cause cardiac injury admitted to Sohag University hospitals, informed written consent has been obtained from each patient; ECG and biochemical analysis of serum cTnI and CK-MB were estimated in all studied patients.</p> <p><strong>Results: </strong>(90%) of studied patients had complete free recovery, (4%) discharged with complications and (6%) of patients died. ECG test can be used as a predictor of mortality and had sensitivity 100%, specificity 46.8% and negative predictive value (NPV) 100%. Serum cTnI was highly significantly increased with death hence could be used as predictors of outcome. While serum CK-MB couldn't be used as an outcome predictor. ROC curve analysis to assess serum cTnI as a predictor of mortality of acute cardiovascular toxicity with cut off &gt; 1.0 ng/ml had sensitivity 100%, specificity 89.4% and NPV 100% with excellent diagnostic characteristic (accuracy rate 96.4%). There is no significant difference of serum CK-MB and serum cTnI among cardiac drugs toxicity patients and non-cardiac toxins patients.</p> <p><strong>Conclusion: </strong>the study concluded that ECG and serum cTnI can be used as a predictor of mortality. Also, the protocol of management will be same in acute cardiotoxicity by cardiac drugs and non-cardiac drugs and toxins.</p> <p><strong>Recommendation:</strong> the study recommends combining of ECG changes and serum cTnI as they can early detect acute cardiovascular effects in acutely poisoned patients.</p> Maha A. Hilal, Sharaf E. D. Mahmoud, Meray M. Shokry, Ahmed M. Said ##submission.copyrightStatement## Mon, 01 Jun 2020 00:00:00 +0000 Balloon Mitral Valvotomy in Gestational Women with Symptomatic Mitral Stenosis <p><strong>Background:</strong> Rheumatic valvular heart disease, commonly mitral stenosis, complicate 1% of pregnancies. Balloon mitral valvuloplasty (BMV) is an established treatment of rheumatic mitral stenosis. Aim of the study was to assess the safety and efficacy of Balloon mitral valvuloplasty in pregnant women with severe mitral stenosis.</p> <p><strong>Materials and Methods:</strong> 66 patients who failed to respond to medical therapy undergoing BMV during pregnancy were analysed in this retrospective study. Mitral valve area (MVA), transmitral Mean valve gradient (MVG), and mitral regurgitation (MR), Pulmonary artery pressure (PAP) were assessed before and 24 hours after the procedure by transthoracic echocardiography. Patients were followed up to one month post BMV and neonates were monitored for the adverse effect of radiation.&nbsp;</p> <p><strong>Results:</strong> Mitral valve area increased from 0.83 ± 0.13 cm<sup>2</sup> to 1.38 ± 0.29 cm<sup>2</sup> (P = 0.007). Mean gradient mitral valve gradient decreased from 15.5 ± 7.4 mmHg to 3.36 ± 2.36 mmHg (P = 0.001). Pulmonary artery pressure decreased from 65.24 ± 17.9 to 50.45 ± 15.33 (P = 0.012). No maternal death, intrauterine growth restriction was observed.</p> <p><strong>Conclusion:</strong> Balloon mitral valvuloplasty has favourable immediate good outcomes for mothers and newborns.</p> Prem Krishna Anandan, Arun Kaushik, K. Tamilarasu, G. Rajendran, Shanmuga Sundaram, P. Ramasamy, R. B. Vidyakar ##submission.copyrightStatement## Thu, 12 Mar 2020 00:00:00 +0000 Electrocardiographic and Echocardiographic Findings in Patients Older than 60 Years: A One Year Pilot Study <p><strong>Background:</strong> Cardiovascular disease (CVD) is the most frequent diagnosis in elderly people and is the leading cause of death in both men and women older than 65 years of age. Age-related vulnerability to CVD is compounded by the cumulative effect of the normal aging process and cardiovascular risk factors over a lifetime. The study assessed the prevalence of electrocardiographic and echocardiographic abnormalities in patients older than 60 years at the geriatric unit of the University of Port-Harcourt Teaching Hospital.</p> <p><strong>Methods:</strong> A cross-sectional study was conducted over 50 patients admitted to the geriatric ward over one year. The subjects underwent blood pressure and anthropometric parameters clinical examinations. Evaluation of the cardiovascular system was done using resting electrocardiogram and echocardiography.</p> <p><strong>Results:</strong> The mean age of the subjects was 68.3±6.3 years with a female preponderance. Out of the 50 studied patients, 44 were admitted with a diagnosis of heart failure (HF). Preserved ejection fraction was present in 27 out of the 44 patients admitted for HF. Forty-seven patients had an abnormal LV geometry ranging from concentric remodeling to eccentric LV hypertrophy. Diastolic dysfunction was present in majority of the respondents 42 (84%). Resting ECG showed varying degrees of rhythm disturbances. Sinus tachycardia, bradycardia and left anterior fascicular blocks were the most prevalent rhythm disorders. Electrocardiographic LVH and left atrial abnormalities were present in 21 and 27 patients respectively. Prolonged QTc was present in only 4 patients.</p> <p><strong>Conclusion:</strong> Electrocardiographic and ultrasound abnormalities are common in elderly patients and this also reflects the high prevalence of CVD in these groups of patients. Thus, resting ECG and ultrasound should routinely be incorporated as one of the baseline assessments for elderly patients to identify potentially serious heart conditions and also serves as a basis for comparison during subsequent hospitalization.</p> Ajala Aisha Oluwabunmi, Bell-Gam Hope Ilanye ##submission.copyrightStatement## Sat, 23 May 2020 00:00:00 +0000