Association of Metabolic Markers of Insulin Resistance with Blood Pressure in Prehypertensive Adults in Makurdi, Nigeria

Main Article Content

Ayu Agbecha
Rebecca M. Gali
Elija N. Yisa
Chidozie E. Agu

Abstract

Background of Study: Previous studies observed insulin resistance in the hypertensive population. However, evidence-based studies of insulin resistance in prehypertension are scant.

Aim: Our study aimed at determining the presence of insulin resistance and its correlation with blood pressure in prehypertensive adults.

Materials and Methods: This was a case-control study involving randomly selected 70 healthy adults in Makurdi, Nigeria. Anthropometric parameters and metabolic markers of insulin resistance (fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance [HOMA-IR], fasting serum insulin [FSI], triglycerides [TGs], triglyceride/high density lipoprotein cholesterol [HDL-C] ratio [TG/HDL-C]) in apparently healthy adults were measured. The metabolic markers of IR in 35 prehypertensives were compared with anthropometrically matched 35 normotensive controls using the student’s t-test. Associations of blood pressure (systolic-SBP and diastolic-DBP) with metabolic markers of insulin resistance in prehypertensives and normotensives were determined using Pearson correlation analysis.

Results: A significantly elevated (P<0.05) SBP, DBP, FSI, and HOMA-IR was observed in prehypertensives compared to matched normotensive controls. A significant positive correlation (P<0.01) was observed between SBP and insulin (r=0.762), HOMA-IR (r=0.756), TGs (r=0.586), TG/HDL-C (r=0.499); DBP and insulin (r=0.659), HOMA-IR (r=0.634), TGs (r=0.469), TG/HDL-C (r=0.469) in prehypertensives. In normotensives, a significant positive correlation (P<0.05) was observed between DBP and TGs (r=0.371), TG/HDL-C (r=0.376); age (r=0.372), BMI (r=0.523), WC (r=0.338).

Conclusion: Our study shows that insulin resistance is associated with elevated blood pressure and could mediate the progression of normotension through prehypertension to hypertension.

 

Keywords:
Prehypertension, insulin resistance, lipids, blood pressure

Article Details

How to Cite
Agbecha, A., M. Gali, R., N. Yisa, E., & E. Agu, C. (2018). Association of Metabolic Markers of Insulin Resistance with Blood Pressure in Prehypertensive Adults in Makurdi, Nigeria. Cardiology and Angiology: An International Journal, 7(3), 1-11. https://doi.org/10.9734/CA/2018/41565
Section
Original Research Article