Cardiology and Angiology: An International Journal

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Assessment of the Relationship between Reperfusion Success and T-peak to T-end Interval in Patients with ST Elevation Myocardial Infarction Treated with Percutaneous Coronary Intervention or Pharmacoinvasive Therapy

  • Sara Kamel Abdo Elezaby
  • Ayman Ahmed El-Sheikh
  • Mohamed Ahmed Abd Al-Aal
  • Magdi El-Masrie

Cardiology and Angiology: An International Journal, Page 73-82
DOI: 10.9734/ca/2021/v10i430182
Published: 21 December 2021

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Abstract


Background: Acute coronary syndrome encompasses unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI) and ST-segment elevation myocardial infarction (STEMI). STEMI is mostly caused by coronary artery occlusion which treated either by fibrinolytic therapy or primary percutaneous coronary intervention (pPCI). The aim of this work was to investigate the relationship between therapeutic plasma exchange (TPE) interval and successful perfusion in patients with STEMI treated with pPCI or pharmaco-invasive therapy.


Methods: This cohort prospective study was carried out on 60 patients admitted to cardiology department in Tanta University Hospitals with STEMI. All patients were subjected to full medical history taking, clinical examination, laboratory investigations, electrocardiography, transthoracic echo Doppler study, coronary angiography, follow up for early outcome during hospital stay and late outcome after 3 months and assessment of thrombolysis in myocardial infarction (TIMI) flow.


Results: There was a statistically non-significant difference regarding age, gender, hypertension and diabetes between both groups. Regarding vessel affected, in group I, there were 20% with RCA lesion, 46.7% with LAD lesion and 33.3% with LCX lesion while in group II there were 30% with RCA lesion, 43.3% with LAD lesion, 20% with LCX lesion and 6.7% was LM with statistically non-significant difference between the groups. In comparison TPE preprocedural and TPE post-procedural in successful PCI group, there was statistically highly significant difference with P value 0.001. While comparing TPE preprocedural and TPE Postprocedural in failed PCI group, there was statistically non-significant difference with P value =0.09. ROC curve analysis was done to pick up the best cut off value of TPE at admission for prediction of Pharmaco-invasive group which revealed TPE at admission more than 104.5 with sensitivity 73.3% and specificity 63.3%. Area under the curve 0.725 with 95% CI ranged from 0.596 to 0.854.


Conclusions: The present study demonstrated that prolonged TPE interval is associated with ischemia and thus shortened TPE could be used as a marker for reperfusion success. TPE prolongation also associated with poor prognosis in patients with STEMI


Keywords:
  • Reperfusion
  • T-peak
  • T-end
  • myocardial infarction
  • percutaneous coronary intervention
  • pharmaco-invasive therapy.
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How to Cite

Abdo Elezaby, S. K., El-Sheikh, A. A., Abd Al-Aal, M. A., & El-Masrie, M. (2021). Assessment of the Relationship between Reperfusion Success and T-peak to T-end Interval in Patients with ST Elevation Myocardial Infarction Treated with Percutaneous Coronary Intervention or Pharmacoinvasive Therapy. Cardiology and Angiology: An International Journal, 10(4), 73-82. https://doi.org/10.9734/ca/2021/v10i430182
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References

Dai X, Busby-Whitehead J, Alexander KP. Acute coronary syndrome in the older adults. Journal of geriatric cardiology: JGC. 2016;13:101.

Vogel B, Claessen BE, Arnold SV, Chan D, Cohen DJ, Giannitsis E, et al. ST-segment elevation myocardial infarction. Nature Reviews Disease Primers. 2019;5:1-20.

Wallace EL, Kotter JR, Charnigo R, Kuvlieva LB, Smyth SS, Ziada KM, et al. Fibrinolytic therapy versus primary percutaneous coronary interventions for ST-segment elevation myocardial infarction in Kentucky: time to establish systems of care? South Med J. 2013;106:391-8.

Puymirat E, Caudron J, Steg PG, Lemesle G, Cottin Y, Coste P, et al. Prognostic impact of non-compliance with guidelines-recommended times to reperfusion therapy in ST-elevation myocardial infarction. The FAST-MI 2010 registry. European Heart Journal: Acute Cardiovascular Care. 2017;6:26-33.

Pu J, Ding S, Ge H, Han Y, Guo J, Lin R, et al. Efficacy and safety of a pharmaco-invasive strategy with half-dose alteplase versus primary angioplasty in ST-segment–elevation myocardial infarction: EARLY-MYO Trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment–Elevation Myocardial Infarction). Circulation. 2017;136:1462-73.

Tse G, Yan BP. Traditional and novel electrocardiographic conduction and repolarization markers of sudden cardiac death. EP Europace. 2017;19:712-21.

Sogomonian R, Ganesh R, Gowda R. Multiple Culprit Lesions in STEMI-Invitation to Collaborate, A Case Series and Literature Review. Cardiol Vasc Res. 2019;3:1-3.

Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Annals of translational medicine. 2016;4.

Çoner A, Akıncı S, Akküçük MH, Altın C, Müderrisoğlu H. Admission Tpe interval predicts reperfusion success in STEMI patients treated with fibrinolytic agents. Turk Kardiyol Dern Ars. 2020;48:49-57.

Çağdaş M, Karakoyun S, Rencüzoğulları İ, Karabağ Y, Yesin M, Velibey Y, et al. Assessment of the relationship between reperfusion success and T-peak to T-end interval in patients with ST elevation myocardial infarction treated with percutaneous coronary intervention. Anatolian journal of cardiology. 2018;19: 50.

Dwijanarko W, Maharani E, Anggrahini DW. T Peak–T End Interval Alteration as Parameter of Successful Fibrinolysis in Patients with ST Segment Elevation Acute Myocardial Infarction. ACI (Acta Cardiologia Indonesiana).3:14-22.

Özbek SC, Sökmen E. Usefulness of Tp-Te interval and Tp-Te/QT ratio in the prediction of ventricular arrhythmias and mortality in acute STEMI patients undergoing fibrinolytic therapy. J Electrocardiol. 2019;56:100-5.

Elitok A, Ikitimur B, Onur I, Oz F, Emet S, Karaayvaz E, et al. The relationship between T-wave peak-to end interval and ST segment recovery on intracoronary ECG during primary PCI. Eur Rev Med Pharmacol Sci. 2015;19:1086-91.

Szydło K, Wita K, Trusz-Gluza M, Zawada K, Piecuch A, Kulach A, et al. Repolarization parameters in patients with acute ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention with respect to predischarge ST-T pattern: A preliminary study. Cardiology journal. 2009;16:52-6.

15. Azarov JE, Demidova MM, Koul S, Van Der Pals J, Erlinge D, Platonov PG. Progressive increase of the T peak-T end interval is associated with ischaemia-induced ventricular fibrillation in a porcine myocardial infarction model. Ep Europace. 2018;20:880-6.
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