The Association between Platelet Lymphocyte Ratio and In-Hospital Outcomes in Patients with First Attack of Acute ST-elevation Myocardial Infraction following Thrombolysis with Streptokinase in a Tertiary Care Hospital
Asu-Ma Kamal *
Department of Clinical & Interventional Cardiology, Evercare Hospital, Dhaka, Bangladesh.
Maliha Kamal
Department of Pathology, National Institute of Cardiovascular Disease & Hospital, Dhaka, Bangladesh.
Sheam Ahmed
Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh.
Auni Kamal
Department of Anatomy, International Medical College, Tongi, Gazipur, Dhaka, Bangladesh.
Iftequar Alam
Department of Cardiology, National Institute of Cardiovascular Disease & Hospital, Dhaka, Bangladesh.
Mahmood Hasan Khan
Department of Cardiology, Delta Hospital Limited, Dhaka, Bangladesh.
S M Ziaul Haque
Department of Cardiology, Salalah Heart Center, Salalah, Sultanate-e-Oman.
Ruhul Amin
Department of Cardiology, Shaheed Ahsan Ullah Master General Hospital, Tongi, Gazipur, Dhaka, Bangladesh.
Mohamed Naser Thabet Ali
Department of Cardiology, Salalah Heart Center, Salalah, Sultanate-e-Oman.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Platelet Lymphocyte ratio (PLR) has been found to be a good predictor of future adverse cardiovascular outcomes in patients with ST-segment elevation myocardial infarction (STEMI).
Aim: Investigation was done in the aim to detect the role of Platelet Lymphocyte ratio (PLR) in predicting in-hospital adverse cardiac events in patients with STEMI thrombolysed with streptokinase in a tertiary care hospital.
Methods: This cross sectional descriptive study carried out in the Department of Cardiology, Mymensingh Medical College Hospital, Mymensingh for fifteen-month duration from January, 2018 to March, 2019, in STEMI patients, who were thrombolysed with inj. Streptokinase (STK) had blood samples at admission, analyzed complete blood counts for PLR calculation. They were grouped into two, low and high PLR, taking 150 as cut-off. Chi square test was used to compare rate of adverse events and death in hospital stay. Logistic regression analysis was used to estimate predictive ability of PLR for in-hospital cardiac events.
Results: A total of 79 patients among 217 patients had complications. Patients in high PLR group had higher rate of complications (63.6% vs. 21.4%, p <0.001) in hospital than those in low PLR group. Arrhythmias (13.0% vs. 5.0%, p <0.036), Heart failure (45.5% vs. 15.0%, p=0.001), Cardiogenic shock (10.4% vs.3.6%, p <0.001), Death (9.1% vs. 6.4%, p=0.473), occurred more in high PLR group. Mean PLR was significantly different between Group-I and Group-II (96.21±27.79 vs. 233.21±88.20, p<0.001). Multivariate regression analysis showed PLR an independent predictor of in-hospital adverse cardiac events (at 10% level of significance, p = 0.001).
Conclusion: High admission PLR is an independent predictor for in-hospital adverse cardiac events in patients hospitalized for STEMI thrombolysed with streptokinase.
Keywords: Platelet lymphocyte ratio, adverse cardiac events, STEMI, thrombolysis, streptokinase