Angiotensin 1-7: A Second Window of Protection in Hypertensive Patients
Mazin Salaheldin Abdalla Mohamed
Department of Physiology, Napata College, Khartoum, Sudan.
Muntaser Ibrahim
Institute of Endemic Diseases, Khartoum University, Khartoum, Sudan.
Muhanad S. Abdelwhab *
Department of Physiology, Napata College, Khartoum, Sudan.
*Author to whom correspondence should be addressed.
Abstract
The effects of the renin-angiotensin-aldosterone system on the human body are so diverse and our knowledge about them is ever growing. Angiotensin 1-7 has been proven to play protective roles in patients with cardiovascular disorders including but not limited to hypertension.
As is the case with Africa, the prevalence of hypertension in Sudan is rising, and its complications could be delayed by pharmacologically manipulating the levels of renin-angiotensin system metabolites.
The aim of this review is to compare the advantageous and deleterious effects of Angiotensin 2 in contrast to those of Angiotensin 1-7 and to assert the well-established protective effects of Angiotensin 1-7 (systemically and locally) in hypertensive patients
Keywords: Angiotensin 1-7, angiotensin II, RAAS, ACE2 hypertension