Relationship between Duration of Diabetes Mellitus and Gensini Score in Patients Undergoing Diagnostic Coronary Angiography

Eman Mahmoud El-Naghy

Cardiovascular Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Mai Mohamed Salama

Cardiovascular Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Suzan Bayomi El-Hefnawy

Cardiovascular Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Mahmoud Abdel Khalek Abo Omer

Cardiovascular Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

*Author to whom correspondence should be addressed.


Abstract

Background: Gensini (G score) is one of the most widely used scoring systems in cardiology. It is an objective method to determine the coronary artery disease severity according to angiographic findings. The aim of this work was to assess the relation between G score and the chronicity of diabetes mellitus (DM) in cases undergoing coronary angiography.

Methods: This prospective cohort research was carried out on 300 cases with diabetes mellitus (DM) on antidiabetic treatment who were referred to diagnostic coronary angiography for suspected coronary artery disease. G score was calculated for measurement of the coronary artery disease severity. During the period from October 2020 to Aril 2022

Results: Age, smoking, chronicity of DM, cholesterol, triglycerides test, and electrocardiogram were statistically prominent positively related with G score, while female gender was statistically significant negative relation with it. Also. Mean G score was statistically prominent higher in cases with ischemic changes than in cases without ischemic changes. Therefore, the chronicity of DM was statistically significant predictor of G score.

Conclusions: significant positive relation between the G score and the chronicity of DM.

Keywords: Chronicity of DM mellitus, gensini score, diagnostic coronary angiography


How to Cite

El-Naghy , E. M., Salama , M. M., El-Hefnawy , S. B., & Omer , M. A. K. A. (2023). Relationship between Duration of Diabetes Mellitus and Gensini Score in Patients Undergoing Diagnostic Coronary Angiography. Cardiology and Angiology: An International Journal, 12(4), 94–100. https://doi.org/10.9734/ca/2023/v12i4347


References

Townsend N, Wilson L, Bhatnagar P, Wickramasinghe K, Rayner M, Nichols M. Cardiovascular disease in Europe: Epidemiological update 2016. Eur Heart J. 2016;37:3232-45.

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-2016 Update: A report from the american heart association. Circulation. 2016;133:38-360.

Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. Global Burden of Disease and Risk Factors. Washington (DC).

New York: The International Bank for Reconstruction and Development / The World Bank

Oxford University Press

Copyright © 2006, The International Bank for Reconstruction and Development/The World Bank Group.; 2006.

Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 DM and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229-34.

Gu K, Cowie CC, Harris MI. Mortality in adults with and without DM in a national cohort of the U.S. population, 1971-1993. DM Care. 1998;21:1138-45.

Fuller JH, Shipley MJ, Rose G, Jarrett RJ, Keen H. Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall research. Br Med J (Clin Res Ed). 1983;287:867-70.

Nesto RW, Rutter MK. Impact of the atherosclerotic process in cases with DM. Acta Diabetol. 2002;39:22-8.

Moreno PR, Murcia AM, Palacios IF, Leon MN, Bernardi VH, Fuster V, et al. Coronary composition and macrophage infiltration in atherectomy specimens from cases with DM mellitus. Circulation. 2000;102:2180-4.

Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol. 1983;51:606-15.

Neeland IJ, Patel RS, Eshtehardi P, Dhawan S, McDaniel MC, Rab ST, et al. Coronary angiographic scoring systems: An evaluation of their equivalence and validity. Am Heart J. 2012;164:547-52.

Association AD. 2. Classification and diagnosis of DM: standards of medical care in DM—2018. DM care. 2018;41:13-27.

Douglas PS, Hoffmann U, Patel MR, Mark DB, Al-Khalidi HR, Cavanaugh B, et al. Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med. 2015;372: 1291-300.

Goyal BM, Sharma SM, Walia M. B-type natriuretic peptide levels predict extent and coronary artery disease severity in non-ST elevation acute coronary syndrome and normal left ventricular function. Indian Heart J. 2014;66:183-7.

Ghem C, Sarmento-Leite RE, de Quadros AS, Rossetto S, Gottschall CA. Serum bilirubin concentration in cases with an established coronary artery disease. Int Heart J. 2010;51:86-91.

Wei S, Gao C, Wei G, Chen Y, Zhong L, Li X. The level of serum bilirubin associated with coronary lesion types in cases with coronary artery disease. J Cardiovasc Med (Hagerstown). 2012;13:432-8.

Ul Amin R, Ahmedani MAM, Karim M, Raheem A. relation between G score and Chronicity of DM in cases undergoing coronary angiography. Cureus. 2019;11: 4010-25.

Nurkalem Z, Hasdemir H, Ergelen M, Aksu H, Sahin I, Erer B, et al. The relationship between glucose tolerance and coronary artery disease severity using the G score. Angiology. 2010;61:751-5.

Yaseen RI, Beda MY, Ibrahim FA. Relation between Coronary artery disease severity and Insulin Resistance in Diabetic Cases. Egypt J Hosp Med. 2021;84: 2084-9.

Gaber AH, Elkholy TM, Aziz EA, Helmi MM. Glycosylated haemoglubin level and coronary artery disease severity. Med J Cairo Univ. 2014;82:87-93.

Tarchalski J, Guzik P, Wysocki H. Relation between the extent of coronary atherosclerosis and lipid profile. Mol Cell Biochem. 2003;246:25-30.

Saleem T, Mohammad KH, Abdel-Fattah MM, Abbasi AH. Association of glycosylated haemoglobin level and DM mellitus chronicity with the coronary artery disease severity. Diab Vasc Dis Res. 2008;5:184-9.

Su G, Mi S, Tao H, Li Z, Yang H, Zheng H, et al. Association of glycemic variability and the presence and coronary artery disease severity in cases with type 2 DM. Cardiovasc Diabetol. 2011;10: 19-25.