An Evaluation of Anti-hyperlipidemic Activity of Ethanolic Extract of Coccinia grandis Leaves in High Fat Induced Rodent Model

Rifat Ara Nisu

Department of Pharmacy, Faculty of Science and Engineering, City University, Khagan Birulia, Savar Dhaka, Bangladesh.

Faisal Ahmed Nadvi *

Department of Pharmacy, Faculty of Science and Engineering, City University, Khagan Birulia, Savar Dhaka, Bangladesh.

Arjina Akter Ankhi

Department of Pharmacy, Faculty of Science and Engineering, City University, Khagan Birulia, Savar Dhaka, Bangladesh.

Sabnam Roy Suma

Department of Pharmacy, Faculty of Science and Engineering, City University, Khagan Birulia, Savar Dhaka, Bangladesh.

Israt Jahan Papiya

Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

Ankita Bose

School of Pharmacy, BRAC University, Dhaka, Bangladesh.

*Author to whom correspondence should be addressed.


Abstract

In the realm of health research, hyperlipidemia is a condition that has lately become prevalent and is a serious issue. Elevated lipid levels in an individual's body are the primary indicator of hyperlipidemia, a condition defined by increased levels of low-density lipoprotein (LDL), total cholesterol, triglycerides, and high lipoprotein levels. Several pharmacological agents are accessible for the treatment of hyperlipidemia. Nevertheless, human beings throughout the globe also thrive on nature-derived therapeutic items. Coccinia grandis is a noteworthy plant known for its antihyperlipidemic properties among them. In this study, we provided a high-fat diet for the experimental rats to generate hyperlipidemia conditions in this rat model. As per our research methodology, Coccnia grandis was administered to all the rats in the treatment group at three (low, medium and high) distinct dosages. It is eventually revealed that Coccnia grandis may successfully lower (p<0.05) the hyperlipidemic state in both medium and high dosages. Elevated and unusual Triglyceride and Total Cholesterol were observed to be restored following Coccnia grandis medication. However, in the case of HDL and LDL, no substantial drop was detected. A considerable restoration was noted similarly in both instances of SGPT and SGOT. These findings show that our plant has components with antihyperlipidemic action, however the concentrations did not meet the necessary threshold. So, additional investigations are needed to examine the chemical structure and the quantities of the molecule as well as find out about genetic alterations.

Keywords: Hyperlipidemia, Coccnia grandis, HDL, LDL natural product


How to Cite

Nisu , R. A., Nadvi, F. A., Ankhi , A. A., Suma , S. R., Papiya, I. J., & Bose, A. (2024). An Evaluation of Anti-hyperlipidemic Activity of Ethanolic Extract of Coccinia grandis Leaves in High Fat Induced Rodent Model. Cardiology and Angiology: An International Journal, 13(1), 5–11. https://doi.org/10.9734/ca/2024/v13i1387

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